Accumulation of High Levels of Monocytic Myeloid-Derived Suppressor Cells Enhances Graft Survival in Almost Tolerant Kidney Transplant Recipients

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells that suppress immune responses during organ transplantation and participate in mediating long-term graft survival and immune tolerance in animal transplant models. However, their role in regulating transplant tolerance in human subjects is not well understood. In the present study, we investigated the role of MDSCs in mediating long-term graft survival in almost tolerant kidney transplant recipients (ATKTRs) and the mechanism(s) responsible for increasing MDSC numbers in these recipients.

Source: Transplantation Proceedings - April 17, 2018 Category: Transplant Surgery Authors: X.X. Du, Y.L. Guo, Y.P. Zhao, M. Yang, S. Chang, B. Liu, L.J. Cai, Z.K. Chen Source Type: research