Up-regulation of Dyrk1b promote astrocyte activation following lipopolysaccharide-induced neuroinflammation

In this study, in vivo, we demonstrated that Dyrk1b expression was significantly increased and reached a peak at 12  h after LPS injection via Western blot. Double immunofluorescence staining showed that Dyrk1b co-located with GFAP and Ki67. In vitro, the expression of Dyrk1b, Ki67 and cyclinD1 was gradually increased and reached a peak at 12 h in a time-dependent manner after 1 μg/mL LPS stimulation.

Source: Neuropeptides - April 16, 2018 Category: Neuroscience Authors: Mingqing He, Jun Gu, Jinzhou Zhu, Xiaoyan Wang, Chengniu Wang, Chengwei Duan, Yingjie Ni, Xiang Lu, Jianzhong Li Source Type: research