Early Cardiac Involvement Affects Left Ventricular Longitudinal Function in Females Carrying {alpha}-Galactosidase A Mutation: Role of Hybrid Positron Emission Tomography and Magnetic Resonance Imaging and Speckle-Tracking Echocardiography [Original Articles]

Conclusions:
In females carrying α-galactosidase A mutation, focal 18F-FDG uptake represents an early sign of disease-related myocardial damage and is associated with impaired left ventricular longitudinal function. These findings support the hypothesis that inflammation plays an important role in glycosphingolipids storage disorders.

Source: Circulation: Cardiovascular Imaging - April 6, 2018 Category: Radiology Authors: Spinelli, L., Imbriaco, M., Nappi, C., Nicolai, E., Giugliano, G., Ponsiglione, A., Diomiaiuti, T. C., Riccio, E., Duro, G., Pisani, A., Trimarco, B., Cuocolo, A. Tags: Echocardiography, Imaging, Magnetic Resonance Imaging (MRI), Nuclear Cardiology and PET Original Articles Source Type: research