Acute kidney injury during treatment with high-dose cloxacillin: A report of 23 cases and literature review

Cloxacillin, a member of the isoxazolyl penicillin group with oxacillin, dicloxacillin, and flucloxacillin, is a major anti-staphylococcal agent, recommended as first line treatment for a broad range of severe infections due to meticillin-susceptible Staphylococcus aureus (MSSA), and included on the World Health Organization (WHO) list of essential medicines. According to the cloxacillin prescribing information, the maximum dose is 6 g/day, but doses recommended by the European Society of Cardiology for infective endocarditis [1], or the French Society of Infectious Diseases for osteoarticular infections [2] are 8-12 g/day, intravenously, for 2-6 weeks.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research