Hypoxia-Dependent Accumulation of Hypoxia-Inducible Factor-1 Alpha Induces Transient Cell Cycle Arrest in Porcine Trophectoderm Cells

In this study, we determined mechanisms underlying the adaptation of pig embryos to oxygen deficiency in the maternal-conceptus microenvironment in in vitro experiments using our established porcine trophectoderm (pTr) cells in culture. The transition from G1 to S phase in pTr cells was reduced in response to 2% oxygen during a short period (
Source: Theriogenology - Category: Genetics & Stem Cells Authors: Source Type: research