Pharmacokinetics-Pharmacodynamics, Computer Decision Support Technologies, and Antimicrobial Stewardship: The Compass and Rudder

The first guidelines for conducting antimicrobial stewardship in the hospitalized setting were published in 2007. These guidelines recommend that stewardship programs employ the science of pharmacokinetics-pharmacodynamics (PK-PD) as well as adopting computerized decision support (CDS) technologies when possible. The United States Food and Drug Administration have adopted PK-PD as a cornerstone in the evaluation of antimicrobial agents during clinical development. The core principles of PK-PD center around describing the relationship between drug exposure indexed to the susceptibility of the infecting bacterial pathogen and patient response.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research