Successful Treatment of Cytogenetically Normal Acute Myeloid Leukemia With Ten-Eleven Translocation 2 –Isocitrate Dehydrogenase 2 and Additional Sex Comb-like 1–Nucleophosmin Co-mutations by HLA Haploidentical Stem Cell Transplantation: A Case Report and Literature Review

The presence of recurrent gene mutations is increasingly important in acute myeloid leukemia (AML) and sheds new insights into the understanding of leukemogenesis, prognostic evaluation, and clinical therapeutic efficacy. Until now, ten-eleven translocation 2 (TET2) and isocitrate dehydrogenase 2 (IDH2) mutations were reported to be mutually exclusive in AML patients. Similarly, nucleophosmin (NPM1) and additional sex comb-like 1 (ASXL1) mutations were rarely coexisted in AML. A 47-year-old man diagnosed with high-risk AML presented simultaneous mutations of TET2 –IDH2 and NPM1–ASXL1 revealed by next-generation sequencing.

Source: Transplantation Proceedings - April 1, 2018 Category: Transplant Surgery Authors: Y. Liu, Y. Cao, Y. Lin, W.-M. Dong, R.-R. Lin, Q. Gu, X.-B. Xie, W.-Y. Gu Tags: Original Contributions: Case Reports Source Type: research