Adipoq polymorphisms among thais with pre-diabetes.
ADIPOQ POLYMORPHISMS AMONG THAIS WITH PRE-DIABETES.
Southeast Asian J Trop Med Public Health. 2016 Nov;47(6):1306-14
Authors: Chaikhiandee S, Phonrat B, Tungtrongchitr A, Suriyaprom K, Chuengsamarn S, Uttamachai C, Tungtrongchitr R
Abstract
Studies have shown that polymorphisms of adiponectin gene (ADIPOQ)
are associated with risk of developing type 2 diabetes mellitus (T2DM).
However, no studies have investigated the association between genetic variants
of ADIPOQ and pre-diabetes, a group at higher risk for developing T2DM. A
total of 75 pre-diabetes and 130 normal subjects were recruited from volunteers
in Bangkok, Thailand. Individuals with pre-diabetes were selected based on
American Diabetes Association diagnostic criteria. Six ADIPOQ polymorphisms
were genotyped using polymerase chain reaction-restriction fragment length
polymorphism technique. ADIPOQ polymorphism rs266729 C>G is significantly
associated with pre-diabetes (p = 0.006). CG/GG genotypes were found among 60%
and 40% of pre-diabetes and normal subjects, respectively. SNP rs266729 C>G was
associated with increased pre-diabetes risk (OR = 2.64; 95% CI: 1.18-5.89, p = 0.018).
No significant differences were found between pre-diabetes and normal subjects
for other ADIPOQ polymorphisms. However, haplotype analysis revealed that
haplotype GGTAAT is significantly associated with pre-diabetes when compared
with GCGAAC reference haplotype (OR = 22.31; 95% CI: 1.37-361....
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research
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