Surveillance of hiv-1 drug-resistance mutations in thailand from 1999 to 2014.

SURVEILLANCE OF HIV-1 DRUG-RESISTANCE MUTATIONS IN THAILAND FROM 1999 TO 2014. Southeast Asian J Trop Med Public Health. 2017 Mar;48(2):271-81 Authors: Iemwimangsa N, Pasomsub E, Sukasem C, Chantratita W Abstract Antiretroviral resistance has long been a serious problem in Thailand. In order to monitor developmental rate of mutations and its impact of the national policy, frequency of drug-resistance mutations in HIV-1 reverse transcriptase (RT) and protease (PR) were analyzed from 24,279 blood plasma samples collected from 1999 to 2014. HIV-1 drug resistance mutations were influenced by drugs that have been used widely as first-line regimens. M184I/V was the most common (53.1% prevalence) RT inhibitor (NRTI) mutation. Other NRTI-associated mutations increased dramatically after the Universal Coverage Scheme was launched in 2007, but declined on the whole after introduction of the Thai National Guidelines in 2010. However, non-NRTI-associated mutations increased between 1999 and 2007, but have remained constant since, with Y181I/C the most (31.4%) prevalent. PR drug-associated mutations (M36I/L/V, H69K/R and L89I/M/V) previously considered as CRF01_AE polymorphisms constituted > 90% prevalence in all samples. The launch of antiretroviral treatment influenced the pattern of mutations and the Universal Coverage Scheme also impacted the rate of development of resistance mutations on a national scale. Drug resistance trends in Thailan...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research