Blocking “don't eat me” signal of CD47-SIRPα in hematological malignancies, an in-depth review

Hematological malignancies express high levels of CD47 as a mechanism of immune evasion. CD47-SIRP α triggers a cascade of events that inhibit phagocytosis. Preclinical research supports several models of antibody-mediated blockade of CD47-SIRPα resulting in cell death signaling, phagocytosis of cells bearing stress signals, and priming of tumor-specific T cell responses. Four different antibod y molecules designed to target the CD47-SIRPα interaction in malignancy are currently being studied in clinical trials: Hu5F9-G4, CC-90002, TTI-621, and ALX-148.

Source: Blood Reviews - April 13, 2018 Category: Hematology Authors: Atlantis Russ, Anh B. Hua, William R. Montfort, Bushra Rahman, Irbaz Bin Riaz, Muhammad Umar Khalid, Jennifer S. Carew, Steffan T. Nawrocki, Daniel Persky, Faiz Anwer Tags: Review Source Type: research