Mechanistic target of rapamycin (MTOR) protein expression in the tumor and its microenvironment correlates with more aggressive pathology at cystectomy

The mechanistic target of rapamycin (mTOR) has been implicated in driving tumor biology in multiple malignancies, including urothelial carcinoma (UC). We investigate how mTOR and phosphorylated mTOR (pmTOR) protein expression correlate with chemoresponsiveness in the tumor and its microenvironment at final pathologic staging after neoadjuvant chemotherapy (NAC).

Source: Urologic Oncology: Seminars and Original Investigations - April 12, 2018 Category: Urology & Nephrology Authors: Brian R. Winters, Funda Vakar-Lopez, Lisha Brown, Bruce Montgomery, Roland Seiler, Peter C. Black, Joost L. Boormans, Marc Dall ′Era, Elai Davincioni, James Douglas, Ewan A. Gibb, Bas W.G. van Rhijn, Michiel S. van der Heijden, Andrew C. Hsieh, Jonathan Tags: Original article Source Type: research