Complement in pathophysiology and treatment of transplant-associated thrombotic microangiopathies (TA-TMA)

Transplant-associated thrombotic microangiopathy (TA-TMA) is a form of microangiopathy specifically occurring in the context of hematopoietic stem cell transplantation (HSCT). Similarly, to other microangiopathies, TA-TMA is characterized by hemolytic anemia, thrombocytopenia, and organ failure due to endothelial injury. While its clinical association with medications (e.g., calcineurin inhibitors), immune reactions (e.g., graft versus host disease) or infectious complications is well established, the pathophysiology remains largely unknown.
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research