Diabetes Mellitus in Pregnancy Leads to Growth Restriction and Epigenetic Modification of the Srebf2 Gene in Rat FetusesNovelty and Significance [Epigenetics and Maternal Diabetes]

In conclusion, diabetic and hyperlipidemic pregnancy induces neurological, metabolic, and epigenetic alterations in the rat fetus. Srebf2 is a potential candidate mediating intrauterine environment-driven epigenetic changes and later diabetic offspring health.

Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Michaela Golic, Violeta Stoȷanovska, Ivo Bendix, Anika Wehner, Florian Herse, Nadine Haase, Kristin Kraker, Caroline Fischer, Natalia Alenina, Michael Bader, Till Schutte, Mirȷam Schuchardt, Markus van der Giet, Wolfgang Henrich, Dominik N. Tags: Animal Models of Human Disease, Diabetes, Type 2, Pregnancy, Epigenetics Original Articles Source Type: research