Transcriptional profiling of murine osteoblast differentiation based on RNA-seq expression analyses
Osteoblastic differentiation is a multistep process characterized by osteogenic induction of mesenchymal stem cells, which then differentiate into proliferative pre-osteoblasts that produce copious amounts of extracellular matrix, followed by stiffening of the extracellular matrix, and matrix mineralization by hydroxylapatite deposition. Although these processes have been well characterized biologically, a detailed transcriptional analysis of murine primary calvaria osteoblast differentiation based on RNA sequencing (RNA-seq) analyses has not previously been reported.
Source: Bone - Category: Orthopaedics Authors: Layal Abo Khayal, Johannes Gr ünhagen, Ivo Provazník, Stefan Mundlos, Uwe Kornak, Peter N. Robinson, Claus-Eric Ott Tags: Full Length Article Source Type: research