Clinical significance of IgM and IgA class anti-NMDAR antibodies in herpes simplex encephalitis

Herpes simplex encephalitis (HSE) is a devastating disease, in adults almost exclusively caused by herpes simplex virus type 1 (HSV-1). In its natural course the mortality is approximately 70% and even with current state-of-the-art treatment, patients often suffer severe and permanent disabilities [1 –4]. In addition to the cytopathic effect of HSV-1 infection in neuronal cells, the human immune response also causes cellular damage and death due to its necessary but imprecise attempts to control infection.

Source: Journal of Clinical Virology - April 10, 2018 Category: Virology Authors: Gabriel Westman, Azita Sohrabian, Elisabeth Aurelius, Clas Ahlm, Silvia Schliamser, Fredrik Sund, Marie Studahl, Johan R önnelid Source Type: research