Adaptation Of Operational Parameters Of Cold Atmospheric Plasma And Their Role In Cancer Therapy

Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Eda Gjika, Sonali Pal-Ghosh, Li Lin, Gauri Tadvalkar, Zhitong Chen, Colin Young, Jerome Canady, Jonathan Sherman, Mary Ann Stepp, Michael Keidar The evaluation of CAP in cancer treatment has been significantly fueled by the growing demand for more effective therapies. CAP has been reported as a selective treatment method with a higher affinity of inducing cell death in cancer cells while leaving normal cells unharmed. However, the extent of its effectiveness varies significantly per cancer type. Studies have revealed that different types of cancers exhibit different response to treatment when exposed to the same CAP conditions. Therefore, an understanding of the immediate effect of CAP on cancer cells may enable improvement of treatment outcomes [1]. We demonstrated that instantaneous CAP response can be monitored in real-time by RealTime-Glo Assay with results interpreted as cell viability. This creates the possibility for developing an adaptive CAP approach platform which could enable real-time modification of the plasma treatment condition. In particular, the composition of reactive oxygen and nitrogen species (RONS) and the intensity of CAP, which is effected by discharge voltage and length of treatment, can be optimized with a feedback system at regular intervals to minimize the predicted viability of cancer cells [1, 2]. In an in vitro proof-of-concept study cond...
Source: Clinical Plasma Medicine - Category: Research Source Type: research