Non-Thermal Plasma As An Innovative Anticancer Strategy On Leukemia Models

Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Eleonora Turrini, Augusto Stancampiano, Emanuele Simoncelli, Romolo Laurita, Elena Catanzaro, Cinzia Calcabrini, Matteo Gherardi, Vittorio Colombo, Carmela Fimognari Antitumor chemotherapy is often hampered by the low therapeutic index of most anticancer drugs and the development of chemoresistance. Furthermore, in leukemia incidence and death rates in patients are really close to each other, when compared to other kind of tumors; pointing out that efficacy of anticancer therapy is suboptimal. Thus, there is a continuous need for new intervention strategies, endowed with a better pharmaco-toxicological profile. Cold atmospheric plasma (CAP) has gained interest as a promising anticancer strategy and earlier studies demonstrated the “non-aggressive” nature of CAP [1]. Several lines of evidence showed that the anticancer activity of CAP mainly depends on the increase in oxidative and nitrosative stress that leads to tumor cell death [2]. However, mechanisms of CAP-cell interaction are not yet completely understood. In this context, the aim of this work is to unravel CAP anticancer effects on in vitro and ex vivo leukemia models achieved within the Italian national project “Scientific Independence for young Researchers” (SIR), that brings together a multidisciplinary team in the areas of Engineering, Pharmacology and Oncohematology. The cytotoxic impact of different...
Source: Clinical Plasma Medicine - Category: Research Source Type: research