The Role Of Cytoglobin In The Plasma-Treatment Of Melanoma

Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Joey De Backer, Jamoliddin Razzokov, Dietmar Hammerschmid, Carl Mensch, Naresh Kumar, Annemie Bogaerts, Sylvia Dewilde Globins are ancient proteins that are present in all kingdoms of life. At the moment, there are 8 different globins known in vertebrates with distinct expression patterns. Human cytoglobin (CYGB), a member of this globin superfamily, is a hexacoordinated heme-protein that is mostly expressed in fibroblasts and fibroblast-related cells, but is also present in neurons, macrophages, muscles and epithelium. Although globins can have a respiratory function, additional functions such as roles in NO metabolism, signal transduction, lipid metabolism and the detoxification of ROS have been proposed. As a consequence of these different functions and localisations, Cygb probably plays a significant role in different pathological conditions such as fibrosis, neurodegeneration and tumorigenesis. For the latter, CYGB has been proposed to be a candidate tumour-suppressor gene [1] as its downregulation in tumors has been associated with increased cancer cell proliferation and elevated extracellular signalregulated kinase and Akt activation [2]. It has been shown that the highest Cygb expression is seen in melanocytes [3]. Furthermore, melanocyte to melanoma transition has been associated with DNAmethylation induced reduction of Cygb expression. While melanoma is accounti...
Source: Clinical Plasma Medicine - Category: Research Source Type: research