A novel tool against multiresistant bacterial pathogens – lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics

Prior to the introduction of antibiotics into medicine about 70 years ago, bacterial infections represented a major cause of death. Unfortunately, antibiotic resistance developed and is now spreading faster than the launch of new effective antimicrobial drugs into the market, potentially leading to a health crisis in the near future [1]. Nowadays, increasing numbers of infections occur caused by bacteria which are resistant to most of the antibacterial treatments currently available [2]. It is estimated that more than 2,000,000 illnesses and 23,000 deaths are caused by antibiotic resistance in the United States per year [3].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research