Antibiotic resistance and mortality in children with nosocomial bloodstream infection in a teaching hospital in indonesia.
ANTIBIOTIC RESISTANCE AND MORTALITY IN CHILDREN WITH NOSOCOMIAL BLOODSTREAM INFECTION IN A TEACHING HOSPITAL IN
INDONESIA.
Southeast Asian J Trop Med Public Health. 2016 Sep;47(5):983-93
Authors: Murni IK, Duke T, Daley AJ, Kinney S, Soenarto Y
Abstract
Nosocomial infection is a major problem in hospitals worldwide. Understanding
patterns of bacterial etiology and antibiotic susceptibility are important
factors to combating nosocomial infection. Among children with nosocomial
bloodstream infection (BSI), we identified pathogens and determined antibiotics
resistance patterns and mortality rates for antibiotic-susceptible and multidrugresistant
(MDR) infection in patients with nosocomial BSI in pediatric wards
and PICU at Dr Sardjito Hospital, Indonesia during December 2010 to February
2013. Of 174 isolates from 170 patients, 168 pathogens were bacteria, of which
148 were gram-negative. Pseudomonas aeruginosa, Klebsiella spp, Enterobacteriaceae,
Acinetobacter baumanii, and Escherichia coli was found in 55%, 6%, 4%, 1%,
and <1%, respectively of the isolates. Imipenem, amikacin, ciprofloxacin, and
ceftazadime had the highest sensitivity to nosocomial pathogens at 86%, 84%,
84%, and 75%, respectively. Eleven patients had MDR-infections, 7 of whom died.
Among 153 patients infected with bacteria resistant to <3 classes of antibiotics
(non-MDR), mortality was 40%, and among 4 patients with fully drug-susceptible
sepsis only one died. T...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research