Primary evidences of the mechanisms of action of HIV aspartyl peptidase inhibitors on Trypanosoma cruzi trypomastigote forms

Chagas disease is a well-known endemic and neglected disease in Latin America which is caused by the protozoan Trypanosoma cruzi. Additionally, the illness has also become a public health problem in North America, many European and some Western Pacific countries due to population migration from endemic areas [1]. According to estimates, from 7-10 million people are chronically infected with T. cruzi and 10-14 thousands of deaths per year are caused by the parasite [1].

Source: International Journal of Antimicrobial Agents - April 7, 2018 Category: Drugs & Pharmacology Authors: Leandro S. Sangenito, Rubem F.S. Menna-Barreto, Ana Carolina S. Oliveira, Claudia M. d'Avila-Levy, Marta H. Branquinha, Andr é L.S. Santos Source Type: research