The impact of the molecular diagnosis in the surveillance of the Clostridium difficile infection.
The impact of the molecular diagnosis in the surveillance of the Clostridium difficile infection.
Roum Arch Microbiol Immunol. 2016 Jan-Jun;75(1-2):12-7
Authors: Bãicuş A, Cîrstoiu M, Lambru K, Plata F, Cîrstoiu CF
Abstract
Clostridium difficile is the agent of many cases of
antibiotic associated diarrhea. The prevalence of the
toxigenic Clostridium difficile strains was assessed by
real-time PCR between May 2014- January 2015, at the
Emergency University Hospital, Bucharest, Romania. The
incidence of the Clostridium difficile infection was 0.47%.
Among the 1119 stool specimens tested, 165 (13.8%)
were positive for C. difficile toxins A and B by
immunochromatography test. All 165 positive samples
were investigated by real time PCR and 134 (81%)
samples were positive for toxin B and for the binary toxin,
while the rest were positive for toxin B. A high number
of samples positive for binary toxin was recorded in the
General surgery department (29.85%), Neurology
(13.43%), and Internal medicine (12.68%). Many of the
infected patients presented as underlying pathology,
cancer, diabetes mellitus and stroke. A rapid decision
concerning the antibiotic therapy was made, to decrease
the risk of nosocomial spread.
PMID: 29616528 [PubMed - in process]
Source: Roumanian Archives of Microbiology and Immunology - Category: Microbiology Tags: Roum Arch Microbiol Immunol Source Type: research
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