Expression signature of some immunity genes triggered in Apis mellifera carpatica model by Pseudomonas entomophila experimental infection.

Expression signature of some immunity genes triggered in Apis mellifera carpatica model by Pseudomonas entomophila experimental infection. Roum Arch Microbiol Immunol. 2016 Jan-Jun;75(1-2):18-24 Authors: Neagu A, Raþiu AC, Mihalache (Radu) MR, Lazãr V, Chifiriuc MC, Ecovoiu AA Abstract Herein we report the expression profiles of certain immunity genes from Apis mellifera carpatica worker individuals experimentally infected with Pseudomonas entomophila L48 strain. Changes of the relative expression of abaecin, Relish, dorsal, Toll-1, domeless, and Duox genes were monitored by qRT-PCR. Our results were compared with similar ones from Drosophila melanogaster model and suggest that these genes are involved in the anti-infective defense mechanisms. Our study opens investigation avenues for modern prophylactic and therapeutic approaches of infections affecting the honeybees, but also for identifying new orthologous genes involved in the human innate immune response. PMID: 29616529 [PubMed - in process]
Source: Roumanian Archives of Microbiology and Immunology - Category: Microbiology Tags: Roum Arch Microbiol Immunol Source Type: research