Transcriptome analyses reveal FOXA1 dysregulation in mammary and extramammary Paget's disease

Paget's disease (PD) is an uncommon intraepithelial adenocarcinoma with unknown pathogenesis. There are two anatomic subtypes: mammary (MPD) and extramammary (EMPD). Little is known about their molecular characteristics. Our objective was to discover novel molecular markers for PD and its subtypes. In the discovery phase, we used transcriptome analyses to uncover the most differentially expressed genes and pathways in EMPD biopsies compared with normal skin. In the validation phase, we performed immunohistochemistry analyses on the most promising marker (FOXA1) and other markers selected from a literature review (GATA3, estrogen receptor [ER], and androgen receptor [AR]) on independent biopsies of MPD (n=86), EMPD (n=59), and normal skin (n=21).

http://www.humanpathol.com/article/S0046-8177(18)30114-X/fulltext?rss=yes

Source: Human Pathology - April 6, 2018 Category: Pathology Authors: Ruiqin Mai, Songxia Zhou, Shuqin Zhou, Weixiang Zhong, Liangli Hong, Yuanyuan Wang, Shanming Lu, Jikai Pan, Yuansheng Huang, Mingwan Su, Richard Crawford, Youwen Zhou, Guohong Zhang Tags: Original contribution Source Type: research