Thyroxine inhibits resveratrol-caused apoptosis by PD-L1 in ovarian cancer cells

In this study, we examined the mechanism by which T4 impairs resveratrol-induced antiproliferation in human ovarian cancer cells and found that T4 inhibited resveratrol-induced nuclear accumulation of COX-2. Furthermore, T4 increased expression and cytoplasmic accumulation of PD-L1, which in turn acted to retain inducible COX-2 in the cytoplasm. Knockdown of PD-L1 by small hairpin RNA (shRNA) relieved the inhibitory effect of T4 on resveratrol-induced nuclear accumulation of COX-2- and COX-2/p53-dependent gene expression. Thus, T4 inhibits COX-2-dependent apoptosis in ovarian cancer cells by retaining inducible COX-2 with PD-L1 in the cytoplasm. These findings provide new insights into the antagonizing effect of T4 on resveratrol’s anticancer properties.

Source: Endocrine-Related Cancer - April 5, 2018 Category: Endocrinology Authors: Chin, Y.-T., Wei, P.-L., Ho, Y., Nana, A. W., Changou, C. A., Chen, Y.-R., Yang, Y.-C. S., Hsieh, M.-T., Hercbergs, A., Davis, P. J., Shih, Y.-J., Lin, H.-Y. Tags: Research Source Type: research