Architecture of the human GATOR1 and GATOR1 –Rag GTPases complexes

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Nature 556, 7699 (2018). doi:10.1038/nature26158

Authors: Kuang Shen, Rick K. Huang, Edward J. Brignole, Kendall J. Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu & David M. Sabatini
Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex—comprising DEPDC5, NPRL2 and NPRL3—regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvation. GATOR1 components have

Source: Nature - March 28, 2018 Category: Research Authors: Kuang Shen Rick K. Huang Edward J. Brignole Kendall J. Condon Max L. Valenstein Lynne Chantranupong Aimaiti Bomaliyamu Abigail Choe Chuan Hong Zhiheng Yu David M. Sabatini Tags: Article Source Type: research