Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen ¿ urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression

Conclusions: Our findings point out extracellular serine proteases, in particular plasmin, and uPAR as valuable therapeutic targets against ILEI-driven tumor progression and emphasize the prognostic relevance of ILEI localization and a combined ILEI-uPAR marker analysis in human breast cancer.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research