RDRio Mycobacterium tuberculosis lineage in the Brazil/Paraguay/Argentina triple border

The high tuberculosis (TB) incidence rates, the closeness of the cities and the high migration flux on the Brazil/Paraguay/Argentina border deserves an in-depth study, using Mycobacterial Interspersed Repetitive Unit (MIRU) and Spoligotyping genetic markers to explore the impact of the Mycobacterium tuberculosis RDRio lineage on disease transmission and resistance to anti-TB drugs in this setting. Although without the totality of M. tuberculosis isolates causing TB in this studied setting, a number of 97 isolates obtained from sputa samples culture of patients with confirmed TB, from 2013 to 2015, were submitted to 24 loci MIRU, Spoligotyping, detection of RDRio lineage and detection of mutation related to isoniazid and rifampicin resistance by MTBDRplus/DNA STRIP.

Source: Tuberculosis - March 31, 2018 Category: Respiratory Medicine Authors: Aryadne Larissa de Almeida, Regiane Bertin de Lima Scodro, Hayalla Corr êa de Carvalho, Giovana Ferreira Costacurta, Vanessa Pietrowski Baldin, Nathally Claudiane Souza Santos, Luciana Dias Ghiraldi-Lopes, Paula Aline Zanetti Campanerut-Sá, Vera Lucia D Source Type: research