Impact of target interactions on small-molecule drug disposition: an overlooked area

Nature Reviews Drug Discovery 17, 299 (2018).
doi:10.1038/nrd.2018.26

Authors: Robert A. B. van Waterschoot, Neil J. Parrott, Andrés Olivares-Morales, Thierry Lavé, Malcolm Rowland & Dennis A. Smith
The selection of an appropriate drug target, as well as a solid understanding of drug pharmacokinetics and pharmacodynamics, are crucial for successful drug discovery. Although it is generally accepted that the free (unbound) concentration of a drug is the driving force for its pharmacological

Source: Nature Reviews Drug Discovery - February 23, 2018 Category: Drugs & Pharmacology Authors: Robert A. B. van Waterschoot Neil J. Parrott Andr é s Olivares-Morales Thierry Lav é Malcolm Rowland Dennis A. Smith Tags: Correspondence Source Type: research