Biased signalling: from simple switches to allosteric microprocessors

Nature Reviews Drug Discovery 17, 243 (2018). doi:10.1038/nrd.2017.229 Authors: Jeffrey S. Smith, Robert J. Lefkowitz & Sudarshan Rajagopal G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and some of the most common drug targets. It is now well established that GPCRs can signal through multiple transducers, including heterotrimeric G proteins, GPCR kinases and β-arrestins. While these signalling
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research