Association of ESR α XbaI A & gt;G, PvuII T & gt;C and ESR β AlwNI T & gt;C polymorphisms with the risk of adolescent idiopathic scoliosis: a systematic review and genetic meta-analysis

Conclusion This meta-analysis suggests that ESRα XbaI A>G, PvuII T>C and ESRβ AlwNI T>C polymorphisms may not be associated with risk of adolescent idiopathic scoliosis in overall analysis. However, ESRα XbaI A>G might have influence on the susceptibility of adolescent idiopathic scoliosis among Asians. Considering the limited sample size and ethnicity, further larger scaled studies are needed to provide a more precise estimation on the associations.
Source: Revista Brasileira de Ortopedia - Category: Orthopaedics Source Type: research