Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion

• Inflammation and oxidative stress-induced endothelial dysfunction is an important mechanism in the process of ischemia/reperfusion (IR) injury.• Endothelial progenitor cells (EPCs) play crucial role in maintaining vascular endothelium homeostasis and tissue regeneration after vascular injury.• Arginine (Arg) is the precursor of nitric oxide and is considered a conditionally essential amino acid with immune modulatory property.• A single dose of L-Arg administration before reperfusion increases the percentage of EPCs and attenuates inflammatory response in mice with limb IR injury.

Source: Nutrition - March 26, 2018 Category: Nutrition Authors: Kuan-Feng Hsieh, Juey-Ming Shih, Yao-Ming Shih, Man-Hui Pai, Sung-Ling Yeh Source Type: research