Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits

This study characterizes the second hit spectrum in BRCA1 and BRCA2-associated breast and ovarian cancers at both gene loci to investigate if second hit mechanisms are mutually exclusive or able to coincide within the same tumor.

Source: Cancer Letters - March 26, 2018 Category: Cancer & Oncology Authors: Mattias Van Heetvelde, Mieke Van Bockstal, Bruce Poppe, Kathleen Lambein, Toon Rosseel, Lilit Atanesyan, Dieter Deforce, Ivo Van Den Berghe, Kim De Leeneer, Jo Van Dorpe, Anne Vral, Kathleen B.M. Claes Tags: Original Articles Source Type: research