Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared to Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study

Conclusions Z-215 was as effective and well-tolerated as 10 mg RPZ in the treatment of RE in this selected population. CYP2C19 genotype status may not affect the efficacy and safety of Z-215. There were no clear dose-response effects between Z-215 doses in the endoscopic healing of RE. These findings suggest that Z-215 may be one option for the initial treatment of RE.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research