Proteomic content of circulating exosomes in dairy cows with or without uterine infection

In the past few decades, there has been a global decrease in dairy cow reproductive performance. An activated inflammatory system, due to uterine infection, has been associated with decreased cow fertility and as such, there is a need to detect uterine disease earlier. Early detection could be achieved by identifying biomarkers for uterine disease. Exosomes are small nanovesicles known to package and deliver protein, mRNA, and miRNAs to near and distant sites. Therefore, the content of circulating exosomes may have the potential to carry biomarkers for earlier diagnosis of disease.

Source: Theriogenology - March 22, 2018 Category: Genetics & Stem Cells Authors: Fatema B. Almughlliq, Yong Q. Koh, Hassendrini N. Peiris, Kanchan Vaswani, Scott McDougall, Elizabeth M. Graham, Chris R. Burke, Buddhika J. Arachchige, Sarah Reed, Murray D. Mitchell Source Type: research