Biological aspects of chondrosarcoma: leaps and hurdles
Chondrosarcomas are characterized by their chemo- and radioresistance leading to a therapeutic surgical approach which remains the only available treatment with a 10-year survival between 30% and 80% depending on the grade. Non-surgical treatments are under investigation and rely on an accurate biological understanding of drug resistance mechanisms. Novel targeted therapy which represents a new relevant therapeutic approach will open new treatment options by targeting several pathways responsible for processes of proliferation and invasion.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Beno îte Mery, Sophie Espenel, Jean-Baptiste Guy, Chloé Rancoule, Alexis Vallard, Marie-Thérèse Aloy, Claire Rodriguez-Lafrasse, Nicolas Magné Source Type: research