Meeting the needs of breast cancer: a nucleolin ’s perspective

Nucleolin has emerged in the cancer scene as a potential target. Nucleolin participates in various cellular functions controlling different components of RNA and DNA metabolism, including ribosome biogenesis, ribosomal (r)RNA maturation, ribosomal (r)DNA transcription and chromatin structure (Ginisty et al., 1999; Srivastava and Pollard, 1999). Therefore, nucleolin is mainly located at the dense fibrillar and granular regions of the nucleolus and nucleoplasm (Lischwe et al., 1981). Nonetheless, different pools of nucleolin, in the cytoplasm and cell membrane, have also been demonstrated to exhibit important functions (Srivastava and Pollard, 1999; Borer et al., 1989; Semenkovich et al., 1990).
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research