Immunotherapy: Tear down this wall
Nature Reviews Cancer 18, 205 (2018).
doi:10.1038/nrc.2018.22
Author: Ulrike Harjes
Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. Inhibition of TGFβ in non-responders can potentially help to improve outcomes in these patients.
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research