Integrative structure and functional anatomy of a nuclear pore complex

Integrative structure and functional anatomy of a nuclear pore complex

Nature 555, 7697 (2018). doi:10.1038/nature26003

Authors: Seung Joong Kim, Javier Fernandez-Martinez, Ilona Nudelman, Yi Shi, Wenzhu Zhang, Barak Raveh, Thurston Herricks, Brian D. Slaughter, Joanna A. Hogan, Paula Upla, Ilan E. Chemmama, Riccardo Pellarin, Ignacia Echeverria, Manjunatha Shivaraju, Azraa S. Chaudhury, Junjie Wang, Rosemary Williams, Jay R. Unruh, Charles H. Greenberg, Erica Y. Jacobs, Zhiheng Yu, M. Jason de la Cruz, Roxana Mironska, David L. Stokes, John D. Aitchison, Martin F. Jarrold, Jennifer L. Gerton, Steven J. Ludtke, Christopher W. Akey, Brian T. Chait, Andrej Sali & Michael P. Rout
Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined the structure of the entire 552-protein nuclear pore complex

Source: Nature - March 14, 2018 Category: Research Authors: Seung Joong Kim Javier Fernandez-Martinez Ilona Nudelman Yi Shi Wenzhu Zhang Barak Raveh Thurston Herricks Brian D. Slaughter Joanna A. Hogan Paula Upla Ilan E. Chemmama Riccardo Pellarin Ignacia Echeverria Manjunatha Shivaraju Azraa S. Chaudhury Junjie W Tags: Article Source Type: research