Placentation defects are highly prevalent in embryonic lethal mouse mutants
Placentation defects are highly prevalent in embryonic lethal mouse mutants
Nature 555, 7697 (2018). doi:10.1038/nature26002
Authors: Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K. White, Elizabeth Tuck, Edward J. Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M. Busch-Nentwich, Antonella Galli, James C. Smith, Elizabeth Robertson, David J. Adams, Wolfgang J. Weninger, Timothy Mohun & Myriam Hemberger
Large-scale phenotyping efforts have demonstrated that approximately 25–30% of mouse gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused on the embryo and not the placenta, despite the crucial role of this extraembryonic organ for developmental progression. Here we screened 103 embryonic
Source: Nature - Category: Research Authors: Vicente Perez-Garcia Elena Fineberg Robert Wilson Alexander Murray Cecilia Icoresi Mazzeo Catherine Tudor Arnold Sienerth Jacqueline K. White Elizabeth Tuck Edward J. Ryder Diane Gleeson Emma Siragher Hannah Wardle-Jones Nicole Staudt Neha Wali John Colli Tags: Article Source Type: research