< b > < i > Paris Polyphylla < /i > < /b > -Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression

Conclusion:PPVY saponins activate DNA damage response pathway, degrade mutant p53 and stimulate CDKN1A expression, thereby inhibiting BC cell growth. Given their poor absorption via oral administration, PPVY saponins may be applicable for intravesical instillations in BC treatment.Curr Urol 2017;11:131-138
Source: Current Urology - Category: Urology & Nephrology Source Type: research