Evaluation of the Effects of Atorvastatin and Ischemic Postconditioning Preventing on the Ischemia and Reperfusion Injury: Experimental Study in Rats

Introduction: Reperfusion injury leads to systemic morphological and functional
pathological alterations. Some techniques are already estabilished to
attenuate the damage induced by reperfusion. Ischemic preconditioning is one
of the standard procedures. In the last 20 years, several experimental
trials demonstrated that the ischemic postconditioning presents similar
effectiveness. Recently experimental trials demonstrated that statins could
be used as pharmacological preconditioning.Methods: 41 Wistar rats (Rattus norvegicus albinus) were distributed
in 5 groups: Ischemia and Reperfusion (A), Ischemic Postconditioning (B),
...

Source: Brazilian Journal of Cardiovascular Surgery - March 20, 2018 Category: Cardiology Source Type: research