Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation [Molecular Imaging]

Conclusions—
A multiplexed optical imaging technique is presented that allows substrate uptake to be simultaneously quantified in multiple tissues in a high throughput manner. The activation of brown adipose tissue occurs early in the onset of left ventricular hypertrophy, which produces tissue-specific changes in substrate uptake that may play a role in the systemic response to cardiac pressure overload.

Source: Circulation: Cardiovascular Imaging - March 19, 2018 Category: Radiology Authors: Panagia, M., Chen, H. H., Croteau, D., Iris Chen, Y.-C., Ran, C., Luptak, I., Josephson, L., Colucci, W. S., Sosnovik, D. E. Tags: Metabolism, Heart Failure, Hypertrophy, Imaging Molecular Imaging Source Type: research