Prognostic significance of The Wilms ’ Tumor-1 (WT1) rs16754 polymorphism in acute myeloid leukemia

Acute myeloid leukemia is a genetically heterogeneous disease characterized by the accumulation of mutations in hematopoietic progenitor cells [1]. AML is the most common acute leukemia affecting adults and its incidence increases with age [2]. AML is divided in to several cytogenetic risk groups and treatment and prognosis vary among this subtypes [3]. For a therapy decision, it is very important to determine the individual patient's risk and chances of success of a treatment. Prognostic factors are associated with outcome parameters, they can be incorporated into scoring systems and influence therapeutic choice [4].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research