Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation

Although the treatment of acute leukemia using a combination of chemotherapeutic agents showed an improved clinical outcome in the past decades, multidrug resistance (MDR) remains a major obstacle to chemotherapy, as one of the key etiologies for relapse or treatment failure. The mechanism of MDR in leukemia is complex, and involves multiple pathways. One of the best characterized mechanisms involves the efflux function of the P-glycoprotein (P-gp), an ATP-binding cassette transporter localized to the cell membrane and encoded by the human multidrug resistance 1 (MDR1, or ABCB1) gene [1 –3].

Source: Leukemia Research - February 3, 2018 Category: Hematology Authors: Yan-Hua Wang, Yoichi Imai, Masayuki Shiseki, Junji Tanaka, Toshiko Motoji Tags: Research paper Source Type: research