ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma

Acyl-CoA thioesterase 1 (ACOT1) is an important isoform of the ACOT family that catalyzes the reaction of fatty acyl-CoAs to CoA-SH and free fatty acids. Recent studies of gastrointestinal tumor metabolism suggest that there is abnormal metabolism of lipids and fatty acids during tumor progression. However, the function and contribution of ACOT1 in gastric cancer development are still poorly understood. Additionally, GLI3 is a major transcription factor in the regulation of hedgehog (Hh) signaling.

Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Fang Wang, Jingyi Wu, Zhichao Qiu, Xiaosong Ge, Xingxiang Liu, Chun Zhang, Wenhuan Xu, Fengming Wang, Dong Hua, Xiaowei Qi, Yong Mao Tags: Original contribution Source Type: research