Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure [Original Articles]

Conclusions:
We demonstrate, for the first time, that chronic CR, when started after HF established, can ameliorate cardiac dysfunction and improve inotropic reserve. At the molecular level, we find that chronic CR diet significantly improves sympathetic cardiac innervation and β-adrenergic receptor levels in failing myocardium.

Source: Circulation: Heart Failure - March 13, 2018 Category: Cardiology Authors: de Lucia, C., Gambino, G., Petraglia, L., Elia, A., Komici, K., Femminella, G. D., DAmico, M. L., Formisano, R., Borghetti, G., Liccardo, D., Nolano, M., Houser, S. R., Leosco, D., Ferrara, N., Koch, W. J., Rengo, G. Tags: Autonomic Nervous System, Diet and Nutrition, Chronic Ischemic Heart Disease, Heart Failure, Remodeling Original Articles Source Type: research