Lactate in the brain: from metabolic end-product to signalling molecule

Nature Reviews Neuroscience 19, 235 (2018). doi:10.1038/nrn.2018.19 Authors: Pierre J. Magistretti & Igor Allaman Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Review Source Type: research