Sleep: Ever-decreasing ripples

Nature Reviews Neuroscience 19, 184 (2018). doi:10.1038/nrn.2018.27 Author: Sian Lewis Hippocampal synapses undergo homeostatic rebalancing during sleep by a mechanism that might involve sharp-wave–ripples (SWRs). Here, a closed-loop system was devised in which onset of a SWR triggered optogenetic silencing of the hippocampal pyramidal neurons that generate SWRs. SWR silencing in mice abolished spontaneous synaptic
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Research Highlight Source Type: research