Cell biology of the neuron: Untangling the ubiquitin – proteasome system

Nature Reviews Neuroscience 19, 184 (2018). doi:10.1038/nrn.2018.26 Author: Sian Lewis The most common genetic cause of amytrophic lateral sclerosis and frontotemporal dementia is an expanded CCCCGG repeat in C9ORF72, which results in aggregates containing poly-Gly-Ala (poly-GA). Here, cryo-electron tomography of rat primary cultured neurons transfected to express poly-GA tagged with green fluorescent protein revealed
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Research Highlight Source Type: research